yDNA Project
Report 2 November 2007: 25 Marker Analysis |
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Extending the analysis to 25 markers doesn't add much new information. It does show that for the group of 4 profiles that match at 12 markers, 2 still match exactly at 25 markers. At 25 markers you want to see 1 or 2 or 3 total distance so our data is still way more complex than that. (note that the profiles with only 12 markers retained their distance calculation for only the 12 markers.
A common adjustment is noted here from the McGee site: The stepwise model says that each mutation is allowed to change the allele value by exactly one, so a difference of two means that two mutations occurred and a difference of three means that three mutations occurred. The infinite allele model says that the entire difference between allele values, no matter how large, is the result of one mutation. As a "for instance", all of the research companies agree that the dys464 group is best analyzed using the infinite allele method.
Some markers "include" a partner marker, like the dys389 set. hence you need to subtract one from the other before doing a comparison.
We can delve further into that aspect of analysis if there is enough interest. In the meantime, we should at least consider these adjustments as setting a lower end of a distance range. It might help make our complex data more understandable. In the chart below see the revised distance (rev. dist.) column.
As Bill Maney pointed out, profiles 84511 and 74127 are identical on the 2nd half of the 25 markers, and share an interesting couplet (18 30) at markers 448/449;
Profiles 12109 and 97012 also share a few couplets. The 13/13 pattern at the start of the dys464 markers is just so so interesting because, as discussed above, that marker set has special characteristics that make changes maybe not so remarkable. But to also have the 8/9 pattern at the dys459 marker set makes the combination maybe pretty remarkable. Why only maybe? Because even on the revised distance rating the two profiles are at least 4 differences apart. That's enough to make you suspect the pattern is coincidence.
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Graphs were produced using Network © Copyright Fluxus Technology Ltd Median Joining feature by Bandelt H-J, Forster P, Röhl A (1999), and MP feature by Polzin T, Daneschmand S V (2003) , with data calculations as derived using the fabulous McGee Utility by Dean McGee; Spreadsheets built with Microsoft Excel 2003
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